Nuovi farmaci ad azione antivirale diretta

New direct acting antivirals

Daniele Serranti1, Giuseppe Indolfi1,2

1Epatologia Pediatrica, Azienda Ospedaliero-Universitaria Meyer 2Dipartimento NEUROFARBA, Università degli Studi di Firenze

Direct acting antivirals active against hepatitis C virus actby inhibiting the crucial steps of the viral lifecycle. Theefficacy of these drugs has been demonstrated to be high(>90%) in adults, adolescents and children with chronichepatitis C. Three different combinations of direct actingantivirals have been approved for use in adolescents (≥12years old): sofosbuvir/ledipasvir, sofosbuvir plus ribavirinand glecaprevir/pibrentasvir. The aim of the present articleis to provide a comprehensive description of the currentknowledge on the use of direct acting antivirals in childrenand adolescents.

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