Formulazioni probiotiche multiceppo: non solo una questione di quantità!

Uno studio di caratterizzazione pre-clinica di efficacia Probiotic multistrain formulations: not just a question of quantity! A pre-clinical characterization’s study of effectiveness

Marina Elli1, Chong-Yoon Lim2, Lorenzo Morelli3

Morelli31AAT-Advanced Analytical Technologies Srl,Piacenza 2Coree Srl, Milano 3Dipartimento di Scienze e Tecnologie Alimentariper una Filiera Agro-Alimentare Sostenibile(DiSTAS), Università Cattolica del Sacro Cuore,Piacenza

The probiotic market offers increasingly mixtures of strainsbelonging to different species and genera (consisting of 2-3different strains or 10 or more). The potential advantage ofcomplex products is mainly associated with the greater quantityof live cells, administered through a single intake. However, mostof the publications focus on the comparison of clinical efficacy ofmulti-strain products with respect to mono-strain products, butmade up of different probiotic strains, thus effectively comparingcompletely different formulations, dosages and methods of intake.In this paper presented a simple and useful pre-clinical probioticassessment tools can be used to compare pure probiotic strainswith different preparations in mixture, in order to guide the choiceof multi-strain formulations, exploiting the potential synergismbetween different strains, minimizing antagonisms andestablishing the most effective quantitative ratio between thecomponents of the mixture.

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