Un’ipertransaminasemia persistente: l’importanza di una buona diagnosidifferenziale

A persistent hypertransaminasemia: the importance of a good differential diagnosis

Annamaria Sapuppo1, Piero Pavone1, Elena Pustorino1, Milena Motta1, Barbara Amato1, Pierluigi Smilari1, Filippo Greco1, Marco Sciveres2, Silvia Riva2, Francesco Cirillo2, Agata Fiumara1

1U.O. di Clinica Pediatrica, Dipartimento di Medicina Clinica eSperimentale, A.O.U. “Policlinico”, P.O.“Gaspare Rodolico”, Università degliStudi di Catania 2IRCCS-ISMETT, Palermo

A 9 year old girl was admitted with headache and dailyabdominal pains; she had HAV hepatitis 8 months beforefollowed by persistent hypertransaminasemia.
The physical examination and the abdominal sonographyshowed only a mild splenomegaly.
Blood tests were normal except for positive HAV IgG andALT-AST high rising.
Hepatic biopsy revealed a picture of autoimmune hepatitisand the therapy was started

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